• Global Water and Climate Adaptation centre (ABCD Centre)

• Applied Centre for Advanced Automotive Research (CAAR)

• Centre for Battery Engineering and Electric Vehicles (CBEEV)

• Centre for Computational Brain Research (CCBR)

• Centre for Excellence in Wireless Technology (CEWIT)

• Centre for Functional Nanomaterials

• Centre for NEMS & Nanophotonics (CNNP)

• Centre for Non-Destructive Evaluation

• Centre for Railway Research (CRR)

• Centre for Social Innovation & Entrepreneurship (CSIE)

• Centre for Technology and Policy (CTaP)

• Centre for Urbanization Buildings and Environment (CUBE)

• Centre of Decentralised Power Systems

• Centre of Excellence (CoE) in Advanced Materials and Manufacturing

• Centre of Excellence in Iron & Steel Technology (COEXIST)

• Centre of Excellence in Urban Transport

• Centre of Excellence on Dam Safety & Dam Rehabilitation

• Centre of Excellence on Machine Tools and Production Technology (AMTDC)

• Centre of Propulsion Technology (CoPT)

• China Studies Centre

• Graphene Applications (TSAMRC)

• Healthcare Technology Innovation Centre( HTIC)

• Indian Solar Energy Harnessing Centre (ISEHC)

• Indo-German Centre for Sustainability (IGCS)

• Initiative in Biological Systems Engineering (IBSE)

• Interdisciplinary Laboratory in Data Sciences (ILDS)

• National Centre for Catalysis Research

• National Centre for Combustion R&D

• National Centre for Safety of Heritage Structures (NCSHS)

• National Technology Centre for Ports, Waterways and Coasts (NTCPWC)

• Raghupathi Singhania Centre of Excellence for Tyre & Vehicle Mechanics

• Reliance-IITM Telecom Centre of Excellence

• Robert Bosch Center for Data Science and Artificial Intelligence

• The Centre for Excellence in Steel Technology (CoExiST)

• Thematic Unit of Excellence (TUE) on Water Purification using Nanotechnology

• Thematic Unit of Excellence on Water

• TTK Centre for Rehabilitation Research and Device Development (R2D2)